AcuScreen CA Cough Analysis technology is a patented A.I. powered Smartphone Application that can accurately detect respiratory diseases by analyzing the sound of a patient coughing. AcuScreen works on most Android smartphones. The app records cough sounds and analyzes them in real-time, producing a statistical likelihood that a specific disease is present. This powerful software has been validated in a robust clinical study to be accurate for the detection and classification of acute tuberculosis (TB). The Specificity and sensitivity of AcuScreen for TB exceeds the WHO standard for a community screening tool for TB detection. AcuScreen is now available for large-scale field studies. New features include a Video Observed Therapy (VOT) module for medication adherence management.